Categories October Surprise 2024 Paroxysmal Nocturnal Hemoglobinuria – StatPearls – NCBI Bookshelf Post author By Post date August 20, 2025 Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease that presents clinically with a variety of symptoms, the most prevalent of which are hemolytic anemia, hemoglobinuria, and somatic symptoms including fatigue and shortness of breath.